Comparison of susceptibility to phagocytosis by mouse peritoneal macrophages between Corynebacterium renale piliated and non-piliated clones.

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  • Corynebacterium renale有線毛及び無線毛クローンのマウス腹腔マクロファージによる食菌作用に対する感受性の比較
  • Corynebacterium renale有線毛及び無線毛クローンのマウス腹腔マクロファージによる食菌作用に対する感受性の比較〔英文〕
  • Corynebacterium renale ユウ センモウ オヨビ ム セン

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Piliated (P+) and non-piliated (P-) bacteria of Corynebacterium renale strain No. 115 were compared in their susceptibility to phagocytosis by mouse peritoneal macrophages. In the absence of opsonins, P+ bacteria were less phagocytized than P- bacteria (P<0.001). Complement at 20% concentraTion enhanced the uptakes of P+ and P- bacteria (P<0.01). In the presence of anti-pili serum, P+ bacteria were phagocytized at a significantly higher rate than P- bacteria (P<0.01), regardless of the presence of complement. The anti-pili monoclonal antibodies 16/5 and 13/4 were also opsonic for P+ bacteria, regardless of the presence of complement, but there was less effect than that of anti-pili polyclonal antibody. In the presence of anti-P+ bacteria serum and complement, P+ bacteria were more significantly phagocytized than P- bacteria (P<0.05), which was possibly due to presence of anti-pili antibody in the anti-P+ bacteria serum. In the presence of anti-P- bacteria serum, the uptake of P+ bacteria was unexpectedly enhanced and bacame nearly equal to that of P- bacteria. The uptake of P- bacteria was nearly constant in all the experiments, except that it was slightly enhanced by the presence of complement.

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