Effect of Fatty Acids on Interaction between Liposome and Amyloid β-peptide

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  • Morita Seiichi
    Department of Materials Science, Wakayama National College of Technology
  • Hamano Yuya
    Department of Materials Science, Wakayama National College of Technology
  • Kuboi Ryoichi
    Department of Chemical Science and Engineering, Graduate School of Engineering Science, Osaka University

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タイトル別名
  • Effect of fatty acids on interaction between liposome and amyloid v peptide

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抄録

In 1, 2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC)/fatty acid (FA) system, the analysis of the interaction between the DMPC/FA liposome and amyloid β-peptide (Aβ) was carried out by using the quartz crystal microbalance (QCM) method, together with the analysis of the compression isotherms of the DMPC/FA monolayer. The DMPC/stearic acid (SA) liposome showed the highest intensity in its interaction with Aβ through the QCM method although the slight interaction between DMPC/linoleic acids (LAs) liposome and Aβ was obtained. The compression isotherm analysis of the lipid monolayers revealed that the DMPC/SA monolayers underwent the distinct phase transfer, with which the interaction between both molecules changed from repulsive to attractive, while DMPC/linoleic acid monolayers did not.

収録刊行物

  • 膜

    膜 32 (4), 215-220, 2007

    日本膜学会

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