Effects of maternal bilateral ureteral ligation on the development of fetal kidney in rats: Histometrical study.

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  • 妊娠ラット両側尿管結紮後の胎仔腎臓の組織形態計測学的研究
  • 妊娠ラット両側尿管結紮後の胎仔腎臓の組織形態計測学的研究〔英文〕
  • ニンシン ラット リョウソク ニョウカン ケッサツゴ ノ タイシ ジンゾウ ノ

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Development of the fetal kidney was studied histometrically following ligation of both ureters of pregnant rats. The operation was performed on day 15, 17, 19 or 21 of gestation, and autopsy was made one day later. In all experimental periods, this operation caused significant changes in neither the "fetal kidney/body" weight ratio nor the size of fetal glomeruli, but induced a significant increase in the number of immature glomeruli per unit renal volume (1 mm3) on day 16 and in the number of mature glomeruli on days 20 and 22 of gestation. It is concluded that the maternal bilateral ureteral ligation does not interfere with the growth of the fetal kidney, but can accelerate fetal glomerular neogenesis and maturation according to the time of operation.

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