Vitamin D2-induced arteriosclerosis in spontaneously hypertensive rats and protection by diltiazem, a calcium antagonist.

DOI JASI Web Site Web Site PubMed

Bibliographic Information

Other Title
  • SHRにおける Vitamin D<SUB>2</SUB> 誘発動脈硬化症および抗Ca剤 diltiazem の効果
  • SHRにおけるVitaminD2誘発動脈硬化症および抗Ca剤diltiazemの効果〔英文〕
  • SHR ニ オケル VitaminD2ユウハツ ドウミャク コウカショウ オヨ

Search this article

Abstract

In male spontaneously hypertensive rats fed an atherogenic diet and treated with vitamin D2 (320, 000 I.U./kg/day) for 4 days, arteriosclerosis of Monckeberg type was produced in the aorta with multiple massive hemorrhage in the periaortic adipose and subdural tissues. The production of vascular changes and hemorrhages was inhibited by oral administration of a calcium antagonist, diltiazem (60 mg/kg-twice/day) for 7 days starting at the first day of vitamin D2 treatment.

Journal

Keywords

Details 詳細情報について

Report a problem

Back to top