非イオン性界面活性剤ベシクルの開発とDDSへの利用

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  • 加藤 敬一
    愛媛大学 大学院理工学研究科　物質生命工学・応用化学コース

書誌事項

タイトル別名
  • Development of Surfactant Vesicle and Application of the Vesicle to DDS
  • ヒイオンセイ カイメン カッセイザイ ベシクル ノ カイハツ ト DDS エノ リヨウ

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説明

Nonionic surfactant Span80 was applied in the preparation of surfactant vesicle (niosome).We revealed that themembrane of Span80 vesicle was consisted of a mixture of sorbitan ester molecules with different four kinds of alkylchains (1~4 chains). Furthermore, the ester composition in the membrane of the vesicles with constant diameter wasfound to be almost constant because the vesicle membrane was constructed by the thermodynamic self–assembly ofthe ester molecules. Thecomparision of thecharacterization between Span80 vesicles and conventional natural–lipidliposomes revealed that the Span80 vesicles had higher values in either fluidity or membrane fusion capability, andlower values in phase-transition temperature as compared with liposomes. The characteristics of Span80 vesicleswere very effective in the application of Span80 vesicles to the drug delivery system (DDS). As a result, we coulddemonstrate the potential application of Span80 vesicles from the experiments in vitroand in vivoasalternatives toconventional liposomes inDDS.

収録刊行物

  • 膜

    膜 33 (6), 285-293, 2008

    日本膜学会

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