受容体活性化とイノシトールリン脂質代謝

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タイトル別名
  • Receptor activation and inositol phospholipids metabolism.
  • ジュヨウタイ カッセイカ イノシトール リン シシツ タイシャ

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Inositol phospholipids hydrolysis is coupled to receptor activation involved in the elevation of intracellular Ca2+and protein kinase C. Recently, this signal transduction system has been paid attention, since this system mediates not only hormonal effects but also cell growth. cell transformation and differentiaton.<BR>In this signal transduction system, guanine nucleotide binding protein.makes important roles in the hydrolysis of inositol phospholipids through lowering Ca2+ for phospholipase C activation. The hydrolysis of phosphatidylinositol 4, 5-bisphoshpate to inositol 1.4, 5-trisphosphate (IP3) and diacylglycerol (DG) produces two important second messengers. IP3 can release Ca2+ from intracellular Ca2+ store and DG can activate protein kinase C. Therefore, this signal transduction system activates two kinases, Ca2+/calmodulin kinase and protein kinase C, which leads to various cellular responses.

収録刊行物

  • 膜

    膜 12 (4), 191-199, 1987

    日本膜学会

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