Application of Membrane Process in Vitamin C Production

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Other Title
  • ビタミンＣ製造における膜分離の用途
  • ビタミンC製造における膜分離の用途--2-keto-L-gulonate回収のためのプレート&フレーム膜分離システム
  • ビタミン C セイゾウ ニ オケル マク ブンリ ノ ヨウト 2 keto L gulonate カイシュウ ノ タメ ノ プレート フレーム マク ブンリ システム
  • Plate & Frame Membrane System for Recovery of 2–keto–L–gulonate
  • 2–keto–L–gulonate回収のためのプレート＆フレーム膜分離システム

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Description

Ultrafiltration with plate & frame membrane system is used for the recovery of 2–keto–L–gulonate (2KLG), animportant intermediate of vitamin C in Northeast General Pharmaceutical Factory, China. Ultrafiltration is a newprocess to remove proteins and bacterial debris in the fermentation broth and the membrane process shows advan-tages over other processes, e.g. precipitation or flocculation. Results of ultrafiltration with two different membranemodules, Alfa Laval M38 and M39 are presented and compared with respect to the characteristics of the two mod-ules. This work shows that fermentation broth without pre-treatment (e.g. centrifugation)can be filtered with the lat-est module M39. The membrane process has been operating in the production line for more than 10 years inNortheast General Pharmaceutical Factory, and the operational experience is summarized in the paper.

Journal

  • MEMBRANE

    MEMBRANE 34 (4), 239-242, 2009

    THE MEMBRANE SOCIETY OF JAPAN

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