Modulatory Effects of Ionized Alkali Mineral Complex(IAMC) on mRNA Expression of Porcine Cytokines.
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- CHOI In-Soo
- Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University
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- SHIN Sung-Jae
- Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University
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- YOO Han Sang
- Department of Infectious Diseases, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University
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It has been recognized that ionized alkali mineral complex (IAMC)-fed farm animals demonstrate higher weight gains but less incidence of diseases than the unfed ones. However, how these beneficial effects in the IAMC-fed animals are induced has not yet been elucidated clearly. In this study, porcine peripheral blood mononuclear cells (PBMC) were cultured for 4, 24, and 48 hr in the presence of IAMC, and the effects of IAMC on mRNA expression of porcine cytokines were evaluated via a reverse transcription-polymerase chain reaction (RT-PCR). Expression levels of IL-4, IL-6, and IL-10 in IAMC-treated cells were usually higher than those in the untreated ones. However, IAMC-treated cells demonstrated a reduced expression of IL-2. In addition, expression of IFN-γ was generally reduced in the cells treated with IAMC. The expression of IL-12 p35 and IL-12 p40 was not detectable in both the untreated and the IAMC-treated cells. Therefore, these results indicate that IAMC has immunomodulatory effects in vitro on the expression of porcine Th1-and Th2-type cytokines.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 63 (11), 1179-1182, 2001
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681400832256
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- NII論文ID
- 110003920771
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD38Xhs12jtQ%3D%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 5984362
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- PubMed
- 11767050
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可