Adhesion of Insect Cells Expressing the Feline Herpesvirus Type 1 Hemagglutinin(gD) to Feline Cell Lines.

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  • MAEDA Ken
    Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
  • ONO Mitsuru
    Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
  • KAWAGUCHI Yasushi
    Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
  • OKAZAKI Katsunori
    Department of Veterinary Hygiene and Microbiology, School of Veterinary Medicine, Hokkaido University
  • YOKOYAMA Naoaki
    Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
  • TOHYA Yukinobu
    Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo
  • MIKAMI Takeshi
    Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo

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  • Adhesion of insect cells expressing the

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Feline herpesvirus type 1 (FHV-1) gD-expressing Sf9 cells adhered to two feline cell lines, but not to the porcine, bovine, or canine cell lines tested. In addition, this adhesion activity was inhibited by a monoclonal antibody against FHV-1 gD. These results showed that the FHV-1 gD might bind to a specific-molecule(s) on the surface of feline cell lines. We discussed a possible importance of the FHV-1 gD in host cell restriction to FHV-1 infection.

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