Effects of Chitin and Chitosan on Collagen Synthesis in Wound Healing

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  • FUJISE Hiroshi
    Department of Veterinary Pathology II, Azabu University, School of Veterinary Medicine
  • OKAMOTO Yoshiharu
    Department of Veterinary Surgery, Faculty of Agriculture, Tottori University
  • MIYATAKE Katsuyuki
    Department of Veterinary Surgery, Faculty of Agriculture, Tottori University
  • SHIGEMASA Yoshihiro
    Department of Materials Science, Faculty of Engineering, Tottori University
  • MINAMI Saburo
    Department of Veterinary Surgery, Faculty of Agriculture, Tottori University
  • KOJIMA Kazuo
    Department of Veterinary Surgery, Faculty of Agriculture, Tottori University
  • KOJIMA Kazuya
    Department of Veterinary Pathology II, Azabu University, School of Veterinary Medicine

書誌事項

公開日
2004
資源種別
journal article
DOI
  • 10.1292/jvms.66.1595
公開者
公益社団法人 日本獣医学会

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説明

Collagen synthesis was evaluated by measuring prolyl hydroxylase (PHL) activity induced within rat granulation tissue by a polyester non-woven fabric (NWF, 1 × 1 cm, 0.6 mm in thickness) impregnated with a chitin or chitosan suspension ranging in concentration from 0.1 to 10 mg/ml. In addition, PHL activity induced in rat granulation tissue by a NWF impregnated with a phosphate buffer solution was examined as a control. The PHL activity in each group remained low until 4 days post-implantation (Day 4). However, in the 10 mg chitin group, the PHL activity increased rapidly without scatter of the data at Day 7 and remained at a plateau until Day 14. In other groups, PHL activity increased linearly until Day 14. The data varied widely at Day 7. Compared to chitosan, chitin at the higher concentration was found to induce stable collagen synthesis in the early wound healing process.<br>

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