Brugia pahangi感染スナネズミの駆虫による同種連続感染に対する抵抗性の誘導(短報)

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  • Protective Immunity against Multiple Challenges of Brugia pahangi in Mongolian Gerbils Induced by Drug-Abbreviated Infection.

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Protective immunity against multiple challenge infections was examined in Mongolian gerbils after a drug-abbreviated infection with Brugia pahangi. The gerbils treated with mebendazole (MBZ) during the late prepatent period (7-9 weeks of postinfection) were challenged with 5 inoculations of 50 infective larvae of B. pahangi at 4-week intervals. The worm burden was significantly reduced 68.6% (19.0 in average number) to that of controls (60.6) and was accompanied with enhanced eosinophil responses 1 week after each challenge. MBZ-treated gerbils suppressed microfilaremia almost completely after the challenge infections.

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