Effects of Oil Adjuvant on Systemic Response to Escherichia coli Lipopolysaccharide in Swine.

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  • 大腸菌リポポリサッカライド (LPS) に対する豚の全身性反応に及ぼすオイルアジュバントの影響
  • Effects of oil adjuvant on systemic res

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Abstract

Intramuscular injection of 0.1 mg/kg of Escherichia coli lipopolysaccharide (LPS) mixed with Freund's complete adjuvant (LPS+FCA) in piglets mititated the leukopenia and TNF-α and cortisol levels in the serum compared with that of LPS suspended in LPS-free saline. The endotoxin level in the serum of the LPS+FCA was remarkably reduced. These results suggest that the addition of oil adjuvant mitigate the systemic toxicity of LPS.

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