Infection of a Chimeric Simian and Human Immunodeficiency Virus with CCR5-Specific HIV-1 Envelope to Rhesus Macaques.
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- ENOSE Yoshimi
- Institute for Virus Research, Kyoto University
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- MIYAKE Ariko
- Institute for Virus Research, Kyoto University
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- IDO Eiji
- Institute for Virus Research, Kyoto University
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- HAYAMI Masanori
- Institute for Virus Research, Kyoto University
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Abstract
Human immunodeficiency virus (HIV) infects lymphocytes and macrophages via CD4 and chemokine receptors. In this study, the infectivity of a chimeric simian and human immunodeficiency virus (SHIV) having a CCR5-specific HIV-1 envelope gene was examined. A SHIV strain termed SHIV-JRFL could enter cells via CD4 with a chemokine receptor CCR5, not CXCR4, and the viral replication was suppressed by recombinant human RANTES, one of β-chemokines. The intravenous inoculation of SHIV-JRFL into two rhesus macaques resulted in a systemic infection, though it was rather weak. During the early infection, the production of RANTES from Con A-stimulated PBMCs of the infected monkeys increased. These results suggested that β-chemokine has the potential to limit the infectivity of an R5-type SHIV.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 65 (2), 283-286, 2003
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681402190080
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- NII Article ID
- 110003886189
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- NII Book ID
- AA10796138
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- COI
- 1:STN:280:DC%2BD3s7ktVSqtQ%3D%3D
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 6477987
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- PubMed
- 12655130
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed