ウシ胎仔胸腺から樹立されたマクロファージ細胞株

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タイトル別名
  • Establishment of a Bovine Macrophage Cell Line from a Fetal Thymus.
  • ウシ胎仔胸腺から樹立されたマクロファージ細胞株(短報)〔英文〕
  • ウシ タイシ キョウセン カラ ジュリツサレタ マクロファージ サイボウカブ

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抄録

A cell line, FBM-17, was established from a fetal bovine thymus and passaged for more than a year. Electron microscopic examination revealed that the cytoplasm contained many phagosomes and a significant amount of rough endoplasmic reticula. In addition, FBM-17 cells showed non-specific esterase, phagocytosis and surface expression of Fc receptors for IgG and classes I and II MHC antigens. These observations confirmed that this cell line had the morphologic and functional features as a macrophage. MHC expression markedly increased by treatment with recombinant bovine gamma-interferon, showing the cell line to be sensitive to bovine gamma-interferon and functional. These present results suggest that the FBM- 17 is a functional bovine macrophage cell line. This line should be useful for clarification of roles of macrophages in immunoregulation in cattle.

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