Androgen- and Estrogen-Dependent Sex Differences in Host Resistance to Strongyloides venezuelensis Infection in Wistar Rats.

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  • RIVERO Juan C.
    Department of Veterinary Teaching Hospital and Internal Medicine, Faculty of Agriculture, Miyazaki University
  • INOUE Yoichi
    Department of Veterinary Teaching Hospital and Internal Medicine, Faculty of Agriculture, Miyazaki University
  • MURAKAMI Noboru
    Department of Veterinary Physiology, Faculty of Agriculture, Miyazaki University
  • HORII Yoichiro
    Department of Veterinary Teaching Hospital and Internal Medicine, Faculty of Agriculture, Miyazaki University

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  • ウィスターラットにおけるベネズエラ糞線虫に対するアンドロゲンおよびエストロゲン依存性の宿主抵抗性の性差

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The effects of male and female sex hormones on the protective capacity of Wistar rats against infection with Strongyloides venezuelensis were investigated. Male rats were more susceptible than females in terms of worm recovery from the lungs. Orchidectomy of male animals significantly reduced the plasma testosterone concentration and increased host resistance to the migratory stages of S. venezuelensis larvae. In contrast, ovariectomy of female animals significantly decreased host resistance in association with a significant reduction of estrogen levels. To examine the direct effect of sex hormones, exogenous testosterone and estrogen were implanted into animals. Susceptibility significantly increased or decreased in ovariectomized females given testosterone or estrogen, respectively. These results suggest that male and female sex hormones are important in the down- and up-regulation of host resistance against S. venezuelensis in Wistar rats.

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