The Identification and Properties of Chitin-binding Protein b01 (CBPb01).
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- SUZUKI Masako
- Department of Veterinary Medicine, Faculty of Agriculture, Iwate University The United Graduate School of Veterinary Sciences, Gifu University
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- MORIMATSU Masami
- Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
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- SYUTO Bunei
- Department of Veterinary Medicine, Faculty of Agriculture, Iwate University
書誌事項
- タイトル別名
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- Identification and Properties of Chitin binding Protein b01 CBPb01
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説明
Bovine serum contains N-acetyl-D-glucosamine (GlcNAc)-sensitive opsonin inhibitory factors. In the present study, a major component of chitin-binding protein (chitin-binding protein b01, CBPb01) was purified from bovine serum, and identified CBPb01 as bovine IgM by its subunit structure, antigenic properties, and partial sequences. The results of a lectin-binding assay showed that the heavy chain of CBPb01 had a GlcNAc structure, but the commercial IgM did not. It is possible that CBPb01 interconnects through its GlcNAc structure, subsequently forming complexes. We also demonstrated that CBPb01 had opsonin-inhibitory activity, and that this activity was dependent on the binding of CBPb01 to GlcNAc on the zymosan surface. These findings indicate the presence of a kind of IgM that recognizes GlcNAc structure in the regulation of opsonization.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 64 (6), 477-481, 2002
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681402218624
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- NII論文ID
- 110003920880
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD38XlvVSmurw%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 6200451
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- PubMed
- 12130830
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可