Massive Cerebral Cortical Necrosis in Suckling Rats Inoculated Intracerebrally with Mouse Hepatitis Virus, A59 Strain

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  • マウス肝炎ウイルスA59株接種ラットにおける大脳皮質壊死について
  • マウス カンエン ウイルス A59 カブ セッシュ ラット ニ オケル ダイノ

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A necrotizing encephalopathy with massive cerebral cortical necrosis was produced in suckling rats inoculated intracerebrally with MHV-A59 strain. After inoculation at 3 days of age most rats died on 6 to 13 days postinoculation showing a central nervous symptom. At autopsy the cornus ammonis was visible through the edematous leptomeninges owing to liquefactive necrosis of the cerebral cortex with increased cerebrospinal fluid in the lesion. By immunofluorescence viral antigen was detected in neurons of the cerebral cortex on day 2 or later postinoculation. Histopathologically degeneration or necrosis of neurons and glial cells were recognized in some liquefactive foci. After inoculation of the same virus at 7 days of age all suckling rats survived, while they had necrotic lesions in the brain, which tended to have repairing process consisting of gliamesenchymal scarring. There were little changes in the brain of rats inoculated at 2 weeks of age.

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