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- YEON Dongsoo
- Department of Physiology, Yonsei University College of Medicine
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- KWON Seongchun
- Department of Physiology, Yonsei University College of Medicine
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- LEE Youngho
- Department of Physiology, Yonsei University College of Medicine
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- LEEM Joongwoo
- Department of Physiology, Yonsei University College of Medicine
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- NAM Taicksang
- Department of Physiology, Yonsei University College of Medicine
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- AHN Ducksun
- Department of Physiology, Yonsei University College of Medicine
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抄録
In the present study mechanism of inhibitory effects of capsaicin on the contractility of rabbit coronary artery were studied by measurement of isometric tension and intracellular Ca2+ concentration. Capsaicin (1 μM to 30 μM) relaxed the coronary artery pre-contracted with prostaglandin (PG) F2α (1 μM) in a concentration-dependent manner. The PGF2 α-induced increase in intracellular Ca2+ concentration was also inhibited. The effects of capsaicin were readily reversed by washing capsaicin from the bath. Capsaicin-induced relaxation was not attenuated by pretreatment with capsazepine (1 μM), a blocker of vanilloid receptor or ruthenium red (1 μM), a blocker of non-selective cation channel. Previous exposure to a high concentration of capsaicin (100 μM) or repeated application of capsaicin did not eliminate the relaxation response to subsequent application of capsaicin. Increasing the external K+ concentration to 80 mM significantly attenuated the capsaicin-induced relaxation with simultaneous change in intracellular Ca2+ concentration. Pretreatment with iberiotoxin (100 nM), a blocker of Ca2+-activated K+ channel, only partially inhibited the capsaicin-induced relaxation. However, application of 4-aminopyridine (4-AP, 1 mM), a blocker of delayed rectifier K+ current significantly inhibited the capsaicin-induced relaxation with concomitant attenuation of the effect on intracellular Ca2+ concentration. These results indicate that capsaicin may have a direct relaxing effect on the smooth muscle contractility, and relaxation may be due to activation of the 4-AP-sensitive, delayed rectifier K+ channels in the rabbit coronary artery.
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 63 (5), 499-503, 2001
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681402611968
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- NII論文ID
- 110003920640
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- NII書誌ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BD3MXkslGqtrY%3D
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 5772346
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- PubMed
- 11411493
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可