INACTIVATION OF HOG CHOLERA VIRUS : II. INACTIVATION WITH NITROGEN MUSTARD COMPOUNDS

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  • 豚コレラ病毒の不活化に関する研究 : II. ナイトロジエン・マスタード化合体による豚コレラ病毒の不活化
  • 豚コレラ病毒の不活化に関する研究〔英文〕-2-
  • トンコレラ ビョウドク ノ フカツカ ニ カンスル ケンキュウ エイブン 2

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Abstract

(1) Not only in tertiary amine compounds, but also in secondary and primary ones, the inactivating ability of nitrogen mustards on hog cholera virus was proven. (2) Destruction of biological activity of hog cholera virus appears not to be related to the chemical groups attached to the nitrogen atom of bis-β-chloroethyl amine. Therefore, significance of virus inactivation may not be attributed to benzyl group. (3) In a single experiment, the inactivation of hog cholera virus was more strongly influenced by monofunctional rather than bifunctional mustard compounds. (4) Triethylenemelamine inactivated hog cholera virus. (5) The basis of inconsistencies for inactivation and variance in immunogenicity of derivative hog cholera virus by nitrogen mustard compounds was discussed.

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