A Study of Metabolites Isolated from the Urine Samples of Cats and Dogs Administered Orbifloxacine

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  • MATSUMOTO Shuji
    Research Laboratories, Animal Science Division, Dainippon Pharmaceutical Co., Ltd.
  • TAKAHASHI Mikio
    Marupi Lifetech Co., Ltd.
  • KITADAI Noriyuki
    Research Laboratories, Animal Science Division, Dainippon Pharmaceutical Co., Ltd.
  • KATAE Hiromi
    Research Laboratories, Animal Science Division, Dainippon Pharmaceutical Co., Ltd.

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  • A Study of Metabolites Isolated from the Urine Samples of Cats and Dogs Administered Orbifloxacin.
  • A Study of Metabolites Isolated from th

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Urine samples of cats and dogs collected for 24 hr after a subcutaneous injection of orbifloxacin (OBFX) were analyzed. The metabolites were examined using HPLC. In the dog urine, 87% of total was the parent compound and 13% glucuronide compound of OBFX and 96% was parent and 4% metabolite in the cat urine. The metabolite of cat urine was identified as N-hydroxy OBFX, determined by comparison of the extraction of urine with chloroform with the standard compound of N-hydroxy OBFX, using LC/APCIMS. N-hydroxy OBFX had a weaker antibacterial activity against fluoroquinolone sensitive bacteria than the parent compound.

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