Aggregability and Post-Transfusion Survival of Canine Platelets in Stored Whole Blood
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- TSUCHIYA Ryo
- Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
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- YAGURA Hisayo
- Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
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- HACHIYA Yoshio
- Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
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- MOCHIZUKI Toshihiko
- Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
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- FURUICHI Mitsuru
- Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
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- HISASUE Masaharu
- Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
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- KOBAYASHI Kosaku
- Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
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- YAMADA Takatsugu
- Laboratory of Internal Medicine II, School of Veterinary Medicine, Azabu University
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Abstract
The effects of whole blood storage time on platelet aggregation and on post-transfusion platelet survival time were assessed in dogs. Citrate phosphate dextrose adenine-1 (CPDA-1) was used as a blood cell preservative. Storage time dependent decay of platelet aggregability was assessed. Platelet aggregation responses to collagen and ADP were maintained for at least 8 hr at room temperature. During blood storage, immunoglobulin became nonspecifically bound to platelets, suggesting the potential for immune destruction of platelets by the mononuclear phagocyte system after transfusion. To assess this assumption, the survival times of infused platelets, which were stored for 0 to 8 hr in whole blood, were measured. Post-transfusion survival of platelets was not affected by these storage times. These results suggest that canine platelets maintain viability when stored at room temperature for up to 8 hr in CPDA-1 treated whole blood intended for transfusion.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 65 (8), 825-829, 2003
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681403037696
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- NII Article ID
- 10013231052
- 110003886267
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- NII Book ID
- AA10796138
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- COI
- 1:STN:280:DC%2BD3svhtFOrtA%3D%3D
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 6684489
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- PubMed
- 12951412
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed