Effect of Administration of Serum Thymic Factor (FTS) in Calves and Rabbits Infected with Bovine Immunodeficiency-Like Virus.

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  • ウシ免疫不全ウイルス感染牛および感染ウサギに対する血清胸腺因子(FTS)投与効果
  • ウシ免疫不全ウイルス感染牛および感染ウサギに対する血清胸腺因子(FTS)投与効果〔英文〕
  • ウシ メンエキ フゼン ウイルス カンセン ウシ オヨビ カンセン ウサギ ニ

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Abstract

The effect of serum thymic factor (FTS) administration in bovine immunodeficiency-like virus (BIV)-infected calves and rabbits was examined. We previously found that some of the macrophage functions were depressed and humoral immune responses against foreign proteins were delayed in BIV-infected calves compared to uninfected calves. After FTS administration, however, no delay of antibody responses against foreign proteins was observed in BIV-infected calves. Though the chemiluminescence (CL) responses of macrophages in BIV-infected calves were significantly depressed (p<0.05), FTS administration resulted in the recovery of the CL responses in the BIV-infected calves comparable to those in the control calves. Antibody responses against foreign proteins in BIV-infected rabbits were significantly depressed (p<0.025) as compared with those in uninfected rabbits, though the depression became no significant after FTS administration.

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