Age-Associated Changes of Flash Visual Evoked Potentials in Dogs

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  • KIMOTSUKI Tomofumi
    Medicinal Safety Research Laboratories, Sankyo Co., Ltd. Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • YASUDA Mitsuya
    Medicinal Safety Research Laboratories, Sankyo Co., Ltd.
  • TAMAHARA Satoshi
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • TOMIHARI Mizuki
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • MATSUKI Naoaki
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • ONO Kenichiro
    Department of Veterinary Clinical Pathobiology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

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  • 犬のフラッシュ刺激視覚誘発電位の加齢に伴う変化

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Abstract

Age-associated changes of visual evoked potentials by flash stimulation (flash VEP) were evaluated in 53 beagle dogs aged from 1- to 15-year-old. Among the components of flash VEP consisted of 3 positive (P1, P2 and P3) and 2 negative (N1 and N2) peaks by 150 msec, the latency of P2 and the later peaks (N2 and P3) were significantly delayed with aging. Both amplitudes of the P2-N2 and N2-P3 also showed a significant correlation with aging. The flash VEP is considered to be an available and useful technique to evaluate not only for visual pathway, but also some disturbance of neurological functions, like as those reported in demented human.<br>

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