Attachment and Infection to MA104 Cells of Avian Rotaviruses Require the Presence of Sialic Acid on the Cell Surface

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  • SUGIYAMA Makoto
    Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
  • GOTO Kazuo
    Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
  • UEMUKAI Hiroko
    Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
  • MORI Yoshio
    Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
  • ITO Naoto
    Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University
  • MINAMOTO Nobuyuki
    Laboratory of Zoonotic Diseases, Faculty of Agriculture, Gifu University

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To determine the characters of receptors on target cells for avian rotaviruses, the receptors on MA104 cells for the pigeon rotavirus PO-13, the turkey rotaviruses Ty-1 and Ty-3, and the chicken rotavirus Ch-1 were analyzed. Pretreatment of MA104 cells with neuraminidase greatly reduced the infection by all of the four avian rotavirus strains. Binding of the cell-attachment protein, purified VP8 expressed in bacteria, of strain PO-13 to MA104 cells was also inhibited by pretreatment of cells with neuraminidase. These findings suggest that avian rotaviruses primarily utilize sialic acid-containing molecules as receptors on MA 104 cells.<br>

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