Cardiovascular Effects of Dobutamine and Phenylephrine Infusion in Sevoflurane-anesthetized Thoroughbred Horses
-
- OHTA Minoru
- Racehorse Clinic, Ritto Training Center, Japan Racing Association (JRA), 1028 Misono, Ritto-shi, Shiga 520–3085, Japan
-
- KURIMOTO Shinjiro
- Racehorse Clinic, Ritto Training Center, Japan Racing Association (JRA), 1028 Misono, Ritto-shi, Shiga 520–3085, Japan
-
- ISHIKAWA Yuhiro
- Racehorse Clinic, Ritto Training Center, Japan Racing Association (JRA), 1028 Misono, Ritto-shi, Shiga 520–3085, Japan
-
- TOKUSHIGE Hirotaka
- Racehorse Clinic, Ritto Training Center, Japan Racing Association (JRA), 1028 Misono, Ritto-shi, Shiga 520–3085, Japan
-
- MAE Naomi
- Racehorse Clinic, Ritto Training Center, Japan Racing Association (JRA), 1028 Misono, Ritto-shi, Shiga 520–3085, Japan
-
- NAGATA Shun-ichi
- Analytical Chemistry Section, Laboratory of Racing Chemistry, 1731–2 Tokami-cyo, Utsunomiya-shi, Tochigi 320–0851, Japan
-
- MAMADA Masayuki
- Racehorse Clinic, Ritto Training Center, Japan Racing Association (JRA), 1028 Misono, Ritto-shi, Shiga 520–3085, Japan
Search this article
Abstract
To determine dose-dependent cardiovascular effects of dobutamine and phenylephrine during anesthesia in horses, increasing doses of dobutamine and phenylephrine were infused to 6 healthy Thoroughbred horses. Anesthesia was induced with xylazine, guaifenesin and thiopental and maintained with sevoflurane at 2.8% of end-tidal concentration in all horses. The horses were positioned in right lateral recumbency and infused 3 increasing doses of dobutamine (0.5, 1.0 and 2.0 µg/kg/min) for 15 min each dose. Following to 30 min of reversal period, 3 increasing doses of phenylephrine (0.25, 0.5 and 1.0 µg/kg/min) were infused. Cardiovascular parameters were measured before and at the end of each 15-min infusion period for each drug. Blood samples were collected every 5 min during phenylephrine infusion period. There were no significant changes in heart rate throughout the infusion period. Both dobutamine and phenylephrine reversed sevoflurane-induced hypotension. Dobutamine increased both mean arterial blood pressure (MAP) and cardiac output (CO) as the result of the increase in stroke volume, whereas phenylephrine increased MAP but decreased CO as the result of the increase in systemic vascular resistance. Plasma phenylephrine concentration increased dose-dependently, and these values at 15, 30 and 45 min were 6.2 ± 1.2, 17.0 ± 4.8 and 37.9 ± 7.3 ng/ml, respectively.
Journal
-
- Journal of Veterinary Medical Science
-
Journal of Veterinary Medical Science 75 (11), 1443-1448, 2013
JAPANESE SOCIETY OF VETERINARY SCIENCE
- Tweet
Details 詳細情報について
-
- CRID
- 1390282681404642560
-
- NII Article ID
- 130003362245
-
- NII Book ID
- AA10796138
-
- COI
- 1:STN:280:DC%2BC3sjos1Gjuw%3D%3D
-
- ISSN
- 13477439
- 09167250
-
- NDL BIB ID
- 025039731
-
- PubMed
- 23832627
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed