Enhanced Protection against Heligmosomoides polygyrus in IL-2 Receptor .BETA.-Chain Overexpressed Transgenic Mice with Intestinal Mastocytosis
-
- MORIMOTO Masahiro
- Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University
-
- UTSUMIYA Kyoko
- Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University
Bibliographic Information
- Other Title
-
- Clinical pathology: Enhanced protection against Heligmosomoides polygyrus in IL-2 receptor β-chain overexpressed transgenic mice with intestinal mastocytosis
- Clinical pathology Enhanced protection against Heligmosomoides polygyrus in IL 2 receptor v chain overexpressed transgenic mice with intestinal mastocytosis
Search this article
Abstract
IL-2 receptor β-chain overexpressed transgenic (Tg2Rβ) mice lack NK cells, but the development of other lymphocyte subsets and macrophages remained apparently intact. These mice also exhibit intestinal mastocytosis. Helminth infection induces various immune responses, such as mast cells, goblet cells, eosinophils and IgE, mediated by Th2 cytokines. IL-4 is also important in the regulation of resistance and susceptibility to Heligmosomoides polygyrus infection. However, there are contradictory results about the relation between resistance to H. polygyrus and intestinal mastocytosis. The present study showed that Tg2Rβ mice suppressed worm fecundity with mastocytosis without an increase of the levels of goblet cells, eosinophils and IgE compared with control mice. These results clearly indicated that mast cells have the ability for to protect against H. polygyrus infection. However, additional studies are required to evaluate protective effector mechanisms against H. polygyrus.<br>
Journal
-
- Journal of Veterinary Medical Science
-
Journal of Veterinary Medical Science 73 (6), 849-851, 2011
JAPANESE SOCIETY OF VETERINARY SCIENCE
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282681404930560
-
- NII Article ID
- 130000445017
-
- NII Book ID
- AA10796138
-
- ISSN
- 13477439
- 09167250
-
- NDL BIB ID
- 11159987
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- CiNii Articles
-
- Abstract License Flag
- Disallowed