Expression of regulatory dendritic cell-related cytokines in cattle experimentally infected with <i>Trypanosoma evansi</i>

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  • MEKATA Hirohisa
    Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060–0818, Japan Project for Zoonoses Education and Research, Department of Veterinary Medicine, Faculty of Agriculture, University of Miyazaki, 1–1 Gakuen-Kibanadai-Nishi, Miyazaki 889–2192, Japan
  • MURATA Shiro
    Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060–0818, Japan
  • MINGALA Claro Niegos
    Animal Health Unit, Philippine Carabao Center National Headquarters and Gene Pool, 3120 Nueva Ecija, Science City of Munoz, Philippines
  • OHASHI Kazuhiko
    Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060–0818, Japan
  • KONNAI Satoru
    Laboratory of Infectious Diseases, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Sapporo 060–0818, Japan

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  • Parasitology : Expression of regulatory dendritic cell-related cytokines in cattle experimentally infected with Trypanosoma evansi

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Trypanosoma evansi causes wasting disease in many livestock. T. evansi infection gives rise to inflammatory immune responses, which contribute to the development of inflammation-associated tissue injury. We previously reported that regulatory dendritic cells (DCs), which act as potential regulators of inflammation, were activated in infected mice and transfer of regulatory DCs to infected mice prolonged their survival. However, the kinetics of regulatory DCs in cattle, which are natural hosts of T. evansi, remained unclear. In this study, we report that the expressions of CCL8 and IL-10, which promote the development of regulatory DCs, were up-regulated in cattle experimentally infected with T. evansi. This finding is potentially useful for studying the control strategy of T. evansi infection in cattle.

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