Systemic T Cell Large Granular Lymphocyte Lymphoma with Multifocal White Matter Degeneration in the Brain of a Japanese Domestic Cat
-
- TSUBOI Masaya
- Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- UCHIDA Kazuyuki
- Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- PARK Eun Sil
- Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- KOTERA Yukiko
- Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- SEKI Takahiro
- Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- TAKAHASHI Masashi
- Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo
-
- NAKAYAMA Hiroyuki
- Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Bibliographic Information
- Other Title
-
- Pathology: Systemic T cell large granular lymphocyte lymphoma with multifocal white matter degeneration in the brain of a Japanese domestic cat
Search this article
Abstract
A 10-year-old spayed female Japanese domestic cat exhibited clinical symptoms suggesting pancreatitis. One month later the cat exhibited Horner's syndrome and was euthanized. At necropsy, multiple neoplastic masses were found in the intestines, spleen, kidneys, urinary bladder, and lungs. On cytology, many neoplastic lymphocytic cells had fine to large cytoplasmic granules, suggesting large granular lymphocyte (LGL) lymphoma. Histopathological examinations revealed infiltrative proliferation of the neoplastic cells in almost organs. Immunohistochemically, the neoplastic cells were intensely positive for CD3 and granzyme B. In the brain, there were multifocal white matter lesions characterized by diffuse myelin loss with mild infiltration of the neoplastic cells. Based on these findings, the cat was diagnosed as LGL lymphoma presumptively of intestinal origin with systemic involvement.<br>
Journal
-
- Journal of Veterinary Medical Science
-
Journal of Veterinary Medical Science 72 (6), 795-799, 2010
JAPANESE SOCIETY OF VETERINARY SCIENCE
- Tweet
Details 詳細情報について
-
- CRID
- 1390282681405321472
-
- NII Article ID
- 130000168017
-
- NII Book ID
- AA10796138
-
- COI
- 1:STN:280:DC%2BC3cnls1Clug%3D%3D
-
- ISSN
- 13477439
- 09167250
-
- NDL BIB ID
- 10750547
-
- PubMed
- 20124761
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed