Immunohistochemical Localization of Aquaporin-4 in the Rat Pituitary Gland
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- KUWAHARA Sachi
- Department of Anatomy and Cell Biology, Hyogo College of Medicine
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- MAEDA Seishi
- Department of Anatomy and Cell Biology, Hyogo College of Medicine
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- ARDILES Yona
- Department of Anatomy and Cell Biology, Hyogo College of Medicine
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- JUN Jin Gon
- Department of Anatomy and Cell Biology, Hyogo College of Medicine
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- TANAKA Koichi
- Department of Anatomy and Cell Biology, Hyogo College of Medicine
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- HAYAKAWA Tetsu
- Department of Anatomy and Cell Biology, Hyogo College of Medicine
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- SEKI Makoto
- Department of Anatomy and Cell Biology, Hyogo College of Medicine
Bibliographic Information
- Other Title
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- Anatomy: Immunohistochemical localization of aquaporin-4 in the rat pituitary gland
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Abstract
Aquaporin-4 (AQP4) is an isoform of membrane water channel aquaporins. It is most abundant in the brain, and is believed to be expressed by astrocytes and ependymal cells. We have reported previously that rat pituitary glands express some aquaporin subtypes, including AQP4, but the precise distribution of AQP4 in the pituitary gland is not known. The present work investigated whether AQP4 immunoreactivity exists in various pituitary cell types in adult rats, using double immunofluorescent staining and confocal microscopy. In the adenohypophysis, co-labeling for S-100 protein indicated that folliculo-stellate (FS) cells and marginal layer cells in Rathke's residual pouch have extensive labeling for AQP4. Some AQP4-expressing cells also contained glial fibrillary acidic protein (GFAP) in parenchymal tissue of the anterior lobe, and cytokeratin in marginal layer cells. AQP4 was not coexpressed in any hormone-producing pituitary cells, however. In the neurohypophysis, AQP4 was expressed in some pituicytes, which have been identified as GFAP-positive. These results suggest that AQP4, which is expressed in FS cells, in marginal layer cells and in pituicytes, but not in hormone-producing cells, is important in water transfer within the pituitary gland; astrocytes and ependymal cells do the same in the brain.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 72 (10), 1307-1312, 2010
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681405389312
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- NII Article ID
- 130000264197
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 10878883
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed