Influence of the Injection Site on the Pharmacokinetics of Cefquinome Following Intramuscular Injection in Piglets

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  • SONG In Bae
    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305–764, South Korea
  • KIM Tae Won
    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305–764, South Korea
  • LEE Hong Gee
    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305–764, South Korea
  • KIM Myoung Seok
    Jeollanamdo Development Institute for Traditional Korean Medicine, Jangheung-gun 529–851, South Korea
  • HWANG Youn Hwan
    Korea Institute of Oriental Medicine, Daejeon 305–811, South Korea
  • PARK Byung Kwon
    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305–764, South Korea
  • LIM Jong Hwan
    B&C Biopharm, Advanced Institutes of Convergence Technology, Suwon-si 443–759, South Korea
  • YUN Hyo In
    Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Chungnam National University, Daejeon 305–764, South Korea

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The aim of the present study was to investigate the influence of different injection sites, i.e., the neck area and thigh muscle, on the pharmacokinetics of cefquinome in piglets following intramuscular (i.m.) injection. Cross-bred (Landrace × Duroc × Yorkshire) piglets were administered the same dose of cefquinome (2 mg/kg body weight) via intravenous injection and intramuscular injection into the neck area or thigh. The mean maximum concentrations (Cmax) of cefquinome following i.m. injection into neck or thigh area were 4.62 ± 0.31 μg/ml at 0.38 ± 0.14 hr and 4.39 ± 0.53 μg/ml at 0.42 ± 0.13 hr, respectively. The absolute bioavailabilities (F) of cefquinome after i.m. injection into the neck or thigh area were 103.04 ± 13.01 and 97.56 ± 16.14%, respectively (P>0.05). There were no differences noted between the two different injection sites for the pharmacokinetic properties of cefquinome after i.m. injection in piglets. Further studies will be needed to determine the incidence or severity of injection site reactions following repeated administrations of cefquinome into both injection sites.

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