Impairment of Renal Function and Electrolyte Balance in Rabbit Hemoorhagic Disease
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- CHEN Sheng-Yi
- Department of Veterinary Medicine, National Chung-Hsing University
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- CHOU Chi-Chung
- Department of Veterinary Medicine, National Chung-Hsing University
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- LIU Cheng-I
- Graduate Institute of Veterinary Pathology, National Chung-Hsing University
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- SHIEN Jui-Hung
- Department of Veterinary Medicine, National Chung-Hsing University
Bibliographic Information
- Other Title
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- Laboratory animal science: Impairment of renal function and electrolyte balance in rabbit hemorrhagic disease
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Abstract
Rabbit hemorrhagic disease virus (RHDV) induced viral fulminant hepatitis in adult rabbits. We investigated the damage of renal function and electrolyte balance in experimentally infected rabbit by measuring the related serum parameters to elucidate the pathogenesis of RHDV as an index for medical treatment. Nineteen New Zealand White rabbits, ten females and nine males, were each intramuscularly inoculated with 0.5 ml 50% rabbit lethal dose (RLD50) rabbit hemorrhagic disease virus. Blood samples were collected at 0 hr post inoculation (HPI) and every 6 hr from 18 HPI repeatedly through 66 HPI. After virus inoculation, serum blood urea nitrogen (BUN), creatinine (CREA) and sodium (Na+) were elevated to a highly significant level (p<0.0001), whereas serum potassium (K+) was moderately elevated to a significant level (p<0.05). Hypoglycemia developed highly significantly (p<0.0001). Serum chloride ion (Cl-) was the only parameter which did not change significantly (p=0.077). No significant sexual difference was observed among these parameters. Renal insufficiency progressed from 36 hr, as indicated by the increases in BUN and CREA; significant changes in electrolytes resulting in the increased osmolality of extracellular fluid that induced flow disturbance which consequently destroy the homeostasis in cells. Therefore, the later impairments in renal function and electrolyte balance might be an important threat for rabbits which might have survived from acute fulminant hepatitis in RHD.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 70 (9), 951-958, 2008
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681405431168
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- NII Article ID
- 110006946011
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 9654780
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed