Physiology: Maternal isobutyl-paraben exposure decreases the plasma corticosterone level in dams and sensitivity to estrogen in female offspring rats

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  • KAWAGUCHI Maiko
    Faculty of Pharmacy and Research Institute of Pharmaceutical Science, Musashino University
  • MOROHOSHI Kaori
    Biological Risk Assessment Section, Environmental Health Sciences Division, National Institute for Environmental Studies
  • MASUDA Junya
    Faculty of Pharmacy and Research Institute of Pharmaceutical Science, Musashino University
  • WATANABE Gen
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
  • MORITA Masatoshi
    Research Center for Environmental Risk, National Institute for Environmental Studies Department of Bioresources, Faculty of Agriculture, Ehime University
  • IMAI Hideki
    Division of Environmental Health Sciences, Department of Social Medicine, Faculty of Medicine, University of Miyazaki
  • TAYA Kazuyoshi
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology Department of Basic Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University
  • HIMI Toshiyuki
    Faculty of Pharmacy and Research Institute of Pharmaceutical Science, Musashino University

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  • Maternal Isobutyl-Paraben Exposure decreases the Plasma Corticosterone Level in Dams and Sensitivity to Estrogen in Female Offspring Rats

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Isobutyl-paraben (IBP), a widely used preservative in a variety of foods, shows high comparative binding affinity to estrogen receptors. Here, we examined the effects of maternal exposure of rats to IBP on plasma hormone concentrations and organ weights in dams, ratio of male pups, anogenital distance, organ weights and plasma hormone concentrations in offspring, puberty, estrous cycle and response of organ weight and plasma hormone concentrations to estrogen in adult female offspring, and reproductive and adrenal function in adult male offspring, all of which are under developmental estrogen regulation, to clarify the estrogenic effects of IBP during gestation and lactation on the endocrine systems of dams and offspring. While maternal exposure of IBP decreased the plasma corticosterone concentration and increased the uterus weight in dams and increased uterine sensitivity to estrogen in adult female offspring, the other indices examined were largely unaffected by the present treatment. Even though these results indicate little sign of endocrine disrupting effects for IBP, the existence of activity may be a matter of concern due to the possible impact on the health of future generations.<br>

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