Pathology: Late Marek's disease in adult chickens inoculated with virulent Marek's disease virus
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- IKEZAWA Mitsutaka
- Department of Pathogenic Veterinary Science, The United Graduated School of Veterinary Sciences, Gifu University Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- GORYO Masanobu
- Department of Pathogenic Veterinary Science, The United Graduated School of Veterinary Sciences, Gifu University Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- SASAKI Jun
- Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
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- HARIDY Mohie
- Department of Pathogenic Veterinary Science, The United Graduated School of Veterinary Sciences, Gifu University
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- OKADA Kosuke
- Department of Pathogenic Veterinary Science, The United Graduated School of Veterinary Sciences, Gifu University Department of Veterinary Pathology, Faculty of Agriculture, Iwate University
書誌事項
- タイトル別名
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- Late Marek's Disease in Adult Chickens Inoculated with Virulent Marek's Disease Virus
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Recently, excessive losses from Marek's disease (MD) have been noted in adult laying flocks over the age of 40 weeks. We defined these late outbreaks in adult chickens as "late MD", and experimentally reproduced the disease in adult SPF P2 line (50-week-old) or commercial line (74-week-old) chickens inoculated with a virulent strain of Marek's disease virus (MDV). Commercial line chickens were given MDV vaccines (HVT and CVI 988) at hatch. The occurrence of MD was evaluated periodically by the evidence of neurologic signs such as paralysis, torticollis, ataxia, and/or nervous tics, as well as histopathological examination. In P2 line chickens, neurologic signs and MD lymphoma were observed from day 21 onward, and they tended to increase in a time-dependent manner. Meanwhile, in commercial line chickens, only one chicken exhibited MD lymphoma on day 70 post inoculation, but its pathogenesis was questionable. No regression of MD lymphoma was noted in either case. The lesions in the visceral organs, thymus, peripheral nerves, and feather pulps of P2 line chickens were characterized by proliferation of variably sized lymphoid cells. In the feather follicle epithelium, numerous inclusion bodies were noted on day 21 post-inoculation, which tended to decrease afterwards. The morphological findings obtained resembled late MD in field cases. In conclusion, our results demonstrate that adult SPF P2 line chickens are susceptible to virulent MDV, and would be useful for investigation of late MD.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 72 (12), 1539-1545, 2010
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681406252800
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- NII論文ID
- 130000307681
- 80021550418
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 10954204
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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