Immune Response of Gnotobiotic Piglets against Mycoplasma hyopneumoniae
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- MUNETA Yoshihiro
- Research Team for Advanced Biologicals, National Institute of Animal Health
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- MINAGAWA Yu
- Research Team for Advanced Biologicals, National Institute of Animal Health
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- SHIMOJI Yoshihiro
- Research Team for Advanced Biologicals, National Institute of Animal Health
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- OGAWA Yohsuke
- Research Team for Advanced Biologicals, National Institute of Animal Health
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- HIKONO Hirokazu
- Research Team for Advanced Biologicals, National Institute of Animal Health
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- MORI Yasuyuki
- Research Team for Paratuberculosis, National Institute of Animal Health
Bibliographic Information
- Other Title
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- Immunology: Immune response of gnotobiotic piglets against Mycoplasma hyopneumoniae
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Abstract
In this study, several cytokine responses were investigated during Mycoplasma hyopneumoniae (Mhp) infection using a gnotobiotic infection model. We found that several inflammatory cytokines (IL-1β, IL-8, IL-18, and TNF-α) and an anti-inflammatory cytokine IL-10 were induced from peripheral blood mononuclear cells (PBMC) of germ-free (GF) piglets stimulated with heat killed Mhp whole antigens, but no IFN-γ and IL-4 were induced by Mhp. After the intranasal infection of Mhp, IL-1β, IL-8, IL-18, and IFN-γ were also detected in the broncho-alveolar lavage fluids (BALF). The antigen-specific IFN-γ and IL-10 responses after infection of Mhp were gradually suppressed during Mhp infection as well as non-specific immune response to concanavalin A (ConA) and lipopolysacchalide (LPS) at early stage of infection. These results suggested that Mhp infection modulates the immune response of pigs by inducing several cytokines, and causes immuno-suppression of pigs in a gnotobiotic condition.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 70 (10), 1065-1070, 2008
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Details 詳細情報について
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- CRID
- 1390282681406343680
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- NII Article ID
- 110006967089
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- NII Book ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 9691348
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed