Effects of Carprofen and Meloxicam with or without Butorphanol on the Minimum Alveolar Concentration of Sevoflurane in Dogs

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  • YAMASHITA Kazuto
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • OKANO Yoshihiko
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • YAMASHITA Maiko
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • UMAR Mohammed A.
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • KUSHIRO Tokiko
    Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
  • MUIR William W.
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University

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  • カルプロフェン-ブトルファノールまたはメロキシカム-ブトルファノール併用による犬のセボフルラン最小肺胞濃度の減少効果
  • Surgery: Effects of carprofen and meloxicam with or without butorphanol on the minimum alveolar concentration of sevoflurane in dogs

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Abstract

Sparing effects of carprofen and meloxicam with or without butorphanol on the minimum alveolar concentration (MAC) of sevoflurane were determined in 6 dogs. Anesthesia was induced and maintained with sevoflurane in oxygen, and MAC was determined by use of a tail clamp method. The dogs were administered a subcutaneous injection of carprofen (4 mg/kg) or meloxicam (0.2 mg/kg), or no medication (control) one hour prior to induction of anesthesia. Following the initial determination of MAC, butorphanol (0.3 mg/kg) was administered intramuscularly, and MAC was determined again. The sevoflurane MACs for carprofen alone (2.10 ± 0.26%) and meloxicam alone (2.06 ± 0.20%) were significantly less than the control (2.39 ± 0.26%). The sevoflurane MACs for the combination of carprofen with butorphanol (1.78 ± 0.20%) and meloxicam with butorphanol (1.66 ± 0.29%) were also significantly less than the control value after the administration of butorphanol (2.12 ± 0.28%). The sevoflurane sparing effects of the combinations of carprofen with butorphanol and meloxicam with butorphanol were additive.<br>

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