Pathology : Cerebellar Ataxia Suspected to Be Caused by Oxytropis glabra Poisoning in Western Mongolian Goats

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  • TAKEDA Shuji
    Department of Veterinary Pathology, Tottori University, Tottori 680–8553, Japan
  • TANAKA Hiroyuki
    Department of Veterinary Pathology, Tottori University, Tottori 680–8553, Japan
  • SHIMADA Akinori
    Laboratory of Pathology, Azabu University, Sagamihara-shi, Kanagawa 252–5201, Japan
  • MORITA Takehito
    Department of Veterinary Pathology, Tottori University, Tottori 680–8553, Japan
  • ISHIHARA Atsushi
    Department of Agricultural Chemistry, Tottori University, Tottori 680–8553, Japan
  • ADILBISH Altanchimeg
    Institute of Veterinary Medicine, Zaisan 210153, Ulaanbaatar, Mongolia
  • DELGERMAA Bayarmunkh
    Institute of Veterinary Medicine, Zaisan 210153, Ulaanbaatar, Mongolia
  • GUNGAA Oyuntsetseg
    Institute of Veterinary Medicine, Zaisan 210153, Ulaanbaatar, Mongolia

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  • Cerebellar Ataxia Suspected to Be Caused by <i>Oxytropis glabra</i> Poisoning in Western Mongolian Goats

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In the last five years in western Mongolia, a neurological disorder and resultant economic loss have developed in goats, sheep, cattle and horses: association of the disease with ingestion of Oxytropis glabra, a toxic plant, was suggested. Affected goats showed neurological signs, including ataxia, incoordination, hind limb paresis, fine head tremor and nystagmus. Three goats, one with moderate clinical signs and the other two with severe clinical signs, were necropsied and examined to describe and characterize the histologic, immunohistochemical and ultrastructural lesions. Although no gross pathological changes were observed in a variety of organs including the central nervous system of these goats, microscopic examination of the cerebellum demonstrated degenerative changes in all these goats, such as vacuolar changes and loss of Purkinje cells, torpedo formation in the granular layer, increased number of spheroids in the cerebellar medulla, and loss of axons and myelin sheaths of Purkinje cells. The chemical analysis of the dried plant detected 0.02–0.05% (dry weight basis) of swainsonine. This is the first report describing the clinical and pathological findings in Mongolian goats suspected to be affected by O. glabra poisoning.

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