Internal Medicine : Evaluation of S100B in cerebrospinal fluid as a potential biomarker for neurological diseases in calves

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  • KOJIMA Yuka
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
  • CHIBA Shiori
    Department of Basic Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
  • HORIUCHI Noriyuki
    Department of Basic Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
  • KOBAYASHI Yoshiyasu
    Department of Basic Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan
  • INOKUMA Hisashi
    Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080–8555, Japan

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  • Evaluation of S100B in cerebrospinal fluid as a potential biomarker for neurological diseases in calves

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S100B in cerebrospinal fluid (CSF-S100B) was measured in calves with 20 neurologic and 21 non-neurologic diseases to clarify its utility as a biomarker for neurologic diseases. The median CSF-S100B value in the neurologic disease group (43.0 ng/ml) was significantly higher than that in the non-neurologic disease group (10.2 ng/ml). As CSF-S100B levels in calves with neurologic diseases widely differed, the utility of CSF-S100B as a diagnostic marker for neurologic diseases in cattle remains inconclusive.

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