MicroRNA expression profiling in canine prostate cancer

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  • KOBAYASHI Masanori
    Laboratory of Reproduction, Division of Therapeutic Science II, Department of Clinical Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • SAITO Akiko
    Laboratory of Reproduction, Division of Therapeutic Science II, Department of Clinical Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • TANAKA Yoshikazu
    Laboratory of Veterinary Hygiene, Division of Veterinary Hygiene and Public Health, Department of Preventive Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • MICHISHITA Masaki
    Laboratory of Veterinary Pathology, Division of Pathobiological Analysis, Department of Veterinary Pathobiology, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • KOBAYASHI Masato
    Laboratory of Veterinary Clinical Pathology, Division of Therapeutic Science I, Department of Clinical Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • IRIMAJIRI Mami
    Laboratory of Veterinary Clinical Pathology, Division of Therapeutic Science I, Department of Clinical Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • KANEDA Takeharu
    Laboratory of Veterinary Pharmacology, Division of Functional Morphology, Department of Basic Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • OCHIAI Kazuhiko
    Department of Basic Science, School of Veterinary Nursing and Technology, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • BONKOBARA Makoto
    Laboratory of Veterinary Clinical Pathology, Division of Therapeutic Science I, Department of Clinical Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • TAKAHASHI Kimimasa
    Laboratory of Veterinary Pathology, Division of Pathobiological Analysis, Department of Veterinary Pathobiology, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • HORI Tatsuya
    Laboratory of Reproduction, Division of Therapeutic Science II, Department of Clinical Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan
  • KAWAKAMI Eiichi
    Laboratory of Reproduction, Division of Therapeutic Science II, Department of Clinical Veterinary Medicine, School of Veterinary Science, Nippon Veterinary and Life Science University, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-8602, Japan

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<p>Canine prostate cancer (cPCa) is an untreatable malignant neoplasm resulting in local tissue invasion and distant metastasis. MicroRNAs (miRs) are small non-coding RNAs that function as oncogenes or tumor suppressors. The purpose of this study was to characterize the expression of miRs that are altered in cPCa tissue. The expression levels of 277 mature miRs in prostatic tissue (n=5, respectively) were compared between the non-tumor and tumor groups using real-time PCR. Five miRs (miR-18a, 95, 221, 222 and 330) were up-regulated, but 14 miRs (miR-127, 148a, 205, 299, 329b, 335, 376a, 376c, 379, 380, 381, 411, 487b and 495) were down-regulated specifically in cPCa (P<0.05). These miRs have potential use as early diagnosis markers for cPCa and in miR-based therapy.</p>

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