Pathology: Non-cytopathic bovine viral diarrhea virus infection inhibits differentiation of bovine neural stem/progenitor cells into astrocytes in vitro
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- MATSUDA Kazuya
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University
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- KOBAYASHI Shintaro
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University
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- KAMEYAMA Ken-ichiro
- Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University
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- SATO Michiko
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University
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- KOIWA Masateru
- Department of Large Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University
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- SAKODA Yoshihiro
- Laboratory of Microbiology, Graduate School of Veterinary Medicine, Hokkaido University
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- TANIYAMA Hiroyuki
- Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University
書誌事項
- タイトル別名
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- Non-Cytopathic Bovine Viral Diarrhea Virus Infection Inhibits Differentiation of Bovine Neural Stem/progenitor Cells into Astrocytes in Vitro
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抄録
Bovine viral diarrhea virus (BVDV) causes fetal brain malformations in ruminants when the fetuses are infected transplacentally in mid-pregnancy. In both cytopathic and non-cytopatic virus infections, viral lytic infection in actively replicating cells and interruption of vascular integrity have been suggested as the pathogenesis, but functional disturbance of infected neural developing cells has been unclear. In this study, we examined the effect of infection with non-cytopathic BVDV2 on the differentiation of neural stem/precursor cells isolated from the bovine fetus. In the process of differentiation to three types of neural cells, neurons, astrocytes and oligodendrocytes, virus infection significantly and selectively inhibited the differentiation of neural stem/precursor cells into the astrocytic lineage. This inhibition is possibly important for the pathogenesis of congenital brain malformations associated with non-cytopathic BVDV infection.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 72 (7), 903-907, 2010
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681407078528
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- NII論文ID
- 130000264274
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 10783026
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可