Molecular and immune mechanisms in the pathogenesis of cardiomyopathy–role of viruses, cytokines, and nitric oxide

DOI Web Site PubMed 被引用文献14件 参考文献176件

書誌事項

タイトル別名
  • Molecular and Immune Mechanisms in the Pathogenesis of Cardiomyopathy
  • Role of Viruses, Cytokines, and Nitric Oxide
公開日
1997
資源種別
journal article
DOI
  • 10.1253/jcj.61.275
公開者
一般社団法人 日本循環器学会

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説明

Myocarditis is thought to be commonly caused by various viruses, and accumulating evidence links viral myocarditis with the eventual development of dilated cardiomyopathy. Recently, the importance of hepatitis C virus infection was noted in patients with dilated and hypertrophic cardiomyopathy. Cytokines are being increasingly recognized as an important factor in the pathogenesis and pathophysiology of myocarditis and cardiomyopathy. Elevated levels of circulating cytokines have been reported in patients with heart failure, and various cytokines have been shown to depress myocardial contractility in vitro and in vivo. A number of reports have shown that cytokines generated by activated immune cells cause an increase in nitric oxide (NO) via induction of NO synthase. Increased generation of NO may induce negative inotropism and myocardial damage. This review discusses the etiology and pathogenesis of myocarditis and cardiomyopathy from this point of view. (Jpn Circ J 1997; 61: 275 - 291)

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