Anatomy: Effects of vitamin E on the osteoblast differentiation
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- SOETA Satoshi
- Department of Veterinary Anatomy, Nippon Veterinary and Animal Science University
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- HIGUCHI Masaya
- Department of Veterinary Anatomy, Nippon Veterinary and Animal Science University
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- YOSHIMURA Itaru
- Animal Farm Institution, Nippon Veterinary and Animal Science University
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- ITOH Ryu
- Akita Prefectural Live Stock Experimental Station
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- KIMURA Nobuhiro
- Laboratory of Animal Nutrition, Nippon Veterinary and Animal Science University
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- AAMSAKI Hajime
- Department of Veterinary Anatomy, Nippon Veterinary and Animal Science University
書誌事項
- タイトル別名
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- Effects of Vitamin E on the Osteoblast Differentiation
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Vitamin E is thought to affect bone formation and bone remodeling. In this study, we investigated the effects of vitamin E (α-tocopherol and δ-tocopherol) on the osteoblasts isolated from rat calvariae. At 4 and 7 days (Day 4 and 7) after induction of osteoblastic differentiation, treatment of α-tocopherol (100 and 200 μM) and δ-tocopherol (2 and 20 μM) for 3 days significantly decreased alkaline phophatase activity of the cultured osteoblasts. At Day 14, however, no significant change was detected in ALP activity and expression of bone sialoprotein mRNA in the osteoblasts treated with α-tocopherol or δ-tocopherol for 3 days. Expression of osteocalcin mRNA was decreased by treatment of α-tocopherol (100 and 200 μM) and δ-tocopherol (2 and 20 μM) at Day 4 and 7. At Day 14, expression of osteocalcin mRNA was decreased only with treatment of 200 μM α-tocopherol. In addition, the noncalcified nodules were decreased by treatment of α-tocopherol (200 μM) and δ-tocopherol (20 μM) at Day 7. However, treatment of α-tocopherol and δ-tocopherol showed no significant change of formation of calcified nodules at Day 14. These results indicate that vitamin E inhibits differentiation of osteoblasts especially from early stage to osteoid-producing stage.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 72 (7), 951-957, 2010
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681407118336
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- NII論文ID
- 130000264269
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 10783162
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 抄録ライセンスフラグ
- 使用不可