Iridociliary adenocarcinoma with oncocytic change in a dog

DOI Web Site Web Site PubMed 2 Citations 17 References
  • OKAWAUCHI Mitsuteru
    Sanritsu Zelkova Veterinary Laboratory, 2–5–8 Kuji, Takatsu-ku, Kawasaki-shi, Kanagawa 213–0032, Japan
  • TSUBOI Masaya
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan
  • NIBE Kazumi
    Sanritsu Zelkova Veterinary Laboratory, 2–5–8 Kuji, Takatsu-ku, Kawasaki-shi, Kanagawa 213–0032, Japan Japan Animal Referral Medical Center Kawasaki, 2–5–8 Kuji, Takatsu-ku, Kawasaki-shi, Kanagawa 213–0032, Japan
  • NAGAMINE Eiji
    Sanritsu Zelkova Veterinary Laboratory, 2–5–8 Kuji, Takatsu-ku, Kawasaki-shi, Kanagawa 213–0032, Japan
  • IWANE Hideaki
    Iwane Animal Clinic, 468, Murokouji, Takizawa-shi, Iwate 020–0634, Japan
  • UCHIDA Kazuyuki
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

Search this article

Abstract

An intraocular mass lesion was found in the left eyeball in a spayed female Pembroke Welsh Corgi dog. The surgically resected left eyeball was pathologically examined. Histologically, the mass lesion consisted of proliferation of the atypical cuboidal or columnar epithelial cells, arranging in papillary, tubular or solid form. In addition, some neoplastic cells showed oncocytic change characterized as large oval cells with numerous eosinophilic intracytoplasmic granules. Cytoplasm of the oncocytic cells showed dark blue granules by phosphotungstic acid-hematoxylin stain. Immunohistochemically, the oncocytic cells were intensely positive for cytochrome C. Based on these findings, the ocular mass was diagnosed as iridociliary adenocarcinoma with oncocytic change. The findings indicate that the oncocytic changes of the neoplastic epithelial cells might be caused by mitochondrial accumulation.

Journal

Citations (2)*help

See more

References(17)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top