Anatomy: Expression of macrophage metalloelastase (MMP-12) in podocytes of hereditary nephrotic mice (ICGN strain)

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  • MANABE Noboru
    Animal Resource Center, The University of Tokyo Research Center for Food Safety, The University of Tokyo
  • SAWADA Kyoko
    Laboratory of Experimental Animal Models, National Institute of Biomedical Innovation
  • UCHIO Kozue
    Laboratory of Experimental Animal Models, National Institute of Biomedical Innovation

書誌事項

タイトル別名
  • Expression of Macrophage Metalloelastase (MMP-12) in Podocytes of Hereditary Nephrotic Mice (ICGN Strain)
公開日
2009
資源種別
journal article
DOI
  • 10.1292/jvms.71.305
公開者
公益社団法人 日本獣医学会

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説明

The Institute for Cancer Research (ICR)-derived glomerulonephritis (ICGN) mouse is a good model for renal fibrosis. In the glomeruli and tubulointerstitium of ICGN mouse kidneys, the components of the extracellular matrix (ECM) accumulated, and matrix metalloproteinases (MMPs) participated in this process. To clarify the mechanism of renal fibrosis, we investigated the expression and localization of macrophage metalloelastase (MMP-12), whose functions in kidney diseases are not fully understood, and its regulatory molecules, monocyte chemoattractive protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2), in the kidneys of ICGN mice by RT-PCR, Western blotting and immunohistochemical staining, respectively. Extensive expression of MMP-12 mRNA and its protein was noted in ICGN mice with progressed nephrotic syndrome. The increase in MMP-12 expression occurred predominantly in podocytes. Furthermore, MCP-1 and CCR2 were also increased in podocytes of the ICGN strain. These results suggest that the expression of MMP-12 is involved in the progression of nephrotic syndrome in ICGN mice.<br>

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