栃(Aesculus turbinata)の実のヘキサン抽出物に含まれるCOX阻害物質の分離・同定

DOI 日本農学文献記事索引 Web Site Web Site 参考文献18件
  • SATO Itaru
    Laboratory of Veterinary Public Health, Faculty of Agriculture, Iwate University
  • KOFUJITA Hisayoshi
    Laboratory of Forest Product Chemistry, Faculty of Agriculture, Iwate University
  • TSUDA Shuji
    Laboratory of Veterinary Public Health, Faculty of Agriculture, Iwate University

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  • Identification of COX Inhibitors in the Hexane Extract of Japanese Horse Chestnut (Aesculus turbinata) Seeds

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抄録

Japanese horse chestnut (Aesculus turbinata) seed extract inhibits the activity of cyclooxygenase (COX), but its active constituents have not been identified. In the present study, COX inhibitors were isolated from the hexane extract of this seed by means of 4 steps of liquid chromatography and were identified by gas chromatography/mass spectrometry and nuclear magnetic resonance. The COX inhibitors in the extract of Japanese horse chestnut seeds were identified as linoleic acid, linolenic acid, and oleic acid. Their efficacies were in the following order: linolenic acid = linoleic acid > oleic acid. These active constituents are C18 unsaturated fatty acids; stearic acid, a C18 saturated fatty acid, had no activity. Linolenic acid and linoleic acid had high selectivity toward COX-2 (selectivity index = 10), whereas oleic acid had no selectivity. Considering the efficacy and yield of each fatty acid, linoleic acid may be the principal COX inhibitor in this seed.<br>

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