Therapeutic Changes of Plasma N-Terminal Pro-Brain Natriuretic Peptide Concentrations in 9 Dogs with Patent Ductus Arteriosus
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- ARAMAKI Yoshitaka
- Chimura Veterinary Hospital Bay Veterinary Hospital
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- CHIMURA Syuuichi
- Chimura Veterinary Hospital
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- HORI Yasutomo
- Department of Small Animal Internal Medicine, School of Veterinary Medicine, Kitasato University
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- EGUCHI Tokuhiro
- Chimura Veterinary Hospital
Bibliographic Information
- Other Title
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- Internal medicine: Therapeutic changes of plasma N-terminal pro-brain natriuretic peptide concentrations in 9 dogs with patent ductus arteriosus
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Abstract
The plasma N-terminal proBNP (NT-proBNP) concentration is measured for determining the diagnosis and severity of heart failure in dogs. However, it is still unclear whether measurements of circulating NT-proBNP levels provide clinical utility as an indicator of therapeutic efficacy. Thus, we investigated the surgical correction-related changes of plasma NT-proBNP concentrations in 9 dogs with patent ductus arteriosus (PDA). Physical examination, thoracic radiography and echocardiography were conducted both before and after surgery. Similarly, the plasma NT-proBNP concentrations were determined using an enzyme immunoassay for canine pro-BNP. The International Small Animal Cardiac Health Council (ISACHC) class and murmur grade were significantly improved after surgery compared with before surgery. Vertebral heart size (VHS) and cardiothoracic ratio (CTR) were significantly decreased after surgery. Fractional shortening was significantly decreased and relative wall thickness (RWT) was significantly increased after surgery. Furthermore, the plasma NT-proBNP concentrations were significantly decreased by surgical correction. The plasma NT-proBNP concentration showed significant positive correlation with the ISACHC class, murmur grade, VHS and CTR and significant negative correlation with the RWT. Therefore, measurement of plasma NT-proBNP levels can be used to monitor the effectiveness of therapies such as surgical correction of PDA.<br>
Journal
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- Journal of Veterinary Medical Science
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Journal of Veterinary Medical Science 73 (1), 83-88, 2011
JAPANESE SOCIETY OF VETERINARY SCIENCE
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Keywords
Details 詳細情報について
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- CRID
- 1390282681407799936
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- NII Article ID
- 40018701687
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- NII Book ID
- AA10796138
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- COI
- 1:CAS:528:DC%2BC3MXivVahtrY%3D
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- ISSN
- 13477439
- 09167250
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- NDL BIB ID
- 10985394
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- PubMed
- 20823663
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed