Pharmacology : Pharmacokinetics of metoclopramide in calves with renal dysfunction

DOI Web Site PubMed 参考文献7件
  • TAKAYASU Mariko
    Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan
  • HAMAMOTO Kouko
    National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Kokubunji, Tokyo 185-8511, Japan
  • SATOH Hiroshi
    Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan
  • ICHIJO Toshihiro
    Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan
  • TAKAHASHI Toru
    Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan
  • FURUHAMA Kazuhisa
    Cooperative Department of Veterinary Medicine, Iwate University, Morioka, Iwate 020-8550, Japan

書誌事項

タイトル別名
  • Pharmacokinetics of metoclopramide in calves with renal dysfunction

この論文をさがす

抄録

To clarify the effect of renal dysfunction on pharmacokinetics of the prokinetic agent metoclopramide (MCP), we administered intravenously 0.4 mg/kg MCP to healthy calves and calves subjected to right kidney vessel ligation (ligation) without or with a subsequent left nephrectomy (ligation plus removal). Plasma MCP concentration, glomerular filtration rate (GFR) and plasma prolactin level were measured by liquid chromatography-tandem mass spectrometry, simplified equation using iodixanol and enzyme-linked immunosorbent assay, respectively. Only in calves with ligation plus removal, plasma MCP concentrations were increased significantly 6, 8 and 12 hr after injection, showing that a negative correlation was observed between the plasma MCP concentrations and GFR value. A tendency to increase in plasma PRL concentration was noted also in these calves. In conclusions, plasma MCP concentrations depend on the GFR mode in calves, and its critical GFR value was estimated.

収録刊行物

参考文献 (7)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ