Streptozotocin-Induced Diabetes Decreases Placenta Growth Factor (PIGF) Levels in Rat Placenta

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  • KOH Phil-Ok
    Department of Anatomy, College of Veterinary Medicine, Reserch Institute of Life Science, Gyeongsang National University
  • SUNG Jin-Hee
    Department of Life Science and Applied Life Science (Brain Korea 21), Gyeongsang National University
  • WON Chung-Kil
    Department of Anatomy, College of Veterinary Medicine, Reserch Institute of Life Science, Gyeongsang National University
  • CHO Jae-Hyeun
    Department of Anatomy, College of Veterinary Medicine, Reserch Institute of Life Science, Gyeongsang National University
  • MOON Jong-Gon
    Department of Anatomy, College of Veterinary Medicine, Reserch Institute of Life Science, Gyeongsang National University
  • PARK Oh-Sung
    Department of Anatomy, College of Veterinary Medicine, Reserch Institute of Life Science, Gyeongsang National University
  • KIM Myeong-Ok
    Department of Life Science and Applied Life Science (Brain Korea 21), Gyeongsang National University

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  • Anatomy: Streptozotocin-induced diabetes decreases placenta growth factor (PIGF) levels in rat placenta

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Abstract

The placenta produces several growth factors, including placenta growth factor (PlGF), which are essential for placenta growth and fetal growth. Diabetic pregnancy induces the abnormal placental growth and fetal development. This study investigated whether diabetes in pregnant rats induces changes in PlGF expression in the placenta. Diabetes was induced by a single intravenous injection of streptozotocin (35 mg/kg body weight) on day 0 of pregnancy, blood and tissue samples were collected on day 20 of pregnancy. In the diabetic group, maternal body weight and fetal weight significantly decreased compared to controls. RT-PCR and Western blot analyses showed that expression of PlGF was significantly decreased in placenta by streptozotocin treatment. Immunohistochemical study showed that the positive signal of PlGF in trophoblast cells was decreased in the diabetic group compared to controls. These findings demonstrate the decline of PlGF in the placenta in diabetic pregnancy.<br>

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