Clinical pathology: Adenosine deaminase activity in cats infected with feline immunodeficiency virus
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- HANKANGA Careen
- Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
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- KOBAYASHI Saori
- Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
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- YAMADA Yuichi
- Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
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- MOMOTA Yutaka
- Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
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- TOMIZAWA Nobuyuki
- Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
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- SATO Reeko
- Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
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- YASUDA Jun
- Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University Department of Veterinary Internal Medicine, Faculty of Agriculture, Iwate University
書誌事項
- タイトル別名
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- Adenosine Deaminase Activity in Cats Infected with Feline Immunodeficiency Virus
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抄録
Adenosine deaminase (ADA), an enzyme involved in purine metabolism, has been shown to be of clinical importance in several diseases in humans. To investigate whether ADA is of any clinical significance in cats, plasma adenosine deaminase (P-ADA) and T cell adenosine deaminase (T-ADA) activities were measured in feline immunodeficiency virus (FIV) negative and positive cats. The AIDS-related complex (ARC) group showed a significant elevation in P-ADA activity compared to the asymptomatic carrier (AC), and FIV-negative groups (P<0.005). T-ADA activity was significantly elevated in FIV-positive cats compared to the FIV-negative group (P<0.05) and this elevation was attributed to the increase in the ARC group (P<0.01). A correlation was found between P-ADA and T-ADA activities in the FIV-negative group. T-ADA activity and CD4+cell number showed a strong negative correlation in FIV-positive cats (P<0.0005). CD4+ cell numbers were significantly reduced in the ARC group compared to the healthy controls (P<0.005). Our results showed that T-ADA is increased in FIV-positive cats during the ARC stage. These results also suggest that ADA may be an indicator of T cell activation in the ARC stage of FIV infection.<br>
収録刊行物
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- The Journal of Veterinary Medical Science
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The Journal of Veterinary Medical Science 69 (9), 881-885, 2007
公益社団法人 日本獣医学会
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詳細情報 詳細情報について
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- CRID
- 1390282681408031232
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- NII論文ID
- 110006388643
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- NII書誌ID
- AA10796138
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- ISSN
- 13477439
- 09167250
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- NDL書誌ID
- 8955094
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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