Human Atrial Natriuretic Peptide Infusion for a Neonate With Congestive Heart Failure After Total Correction of Total Anomalous Pulmonary Venous Connection

DOI Web Site PubMed 9 References Open Access
  • Hamawaki Masayoshi
    Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
  • Tomino Tetsuo
    Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
  • Sato Harumitsu
    Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
  • Imura Masato
    Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
  • Suzuki Takeo
    Department of Cardiovascular Surgery, Ehime Prefectural Central Hospital, Matsuyama
  • Hibino Narutoshi
    The Department of Pediatric Cardiovascular Surgery, The Heart Institute of Japan, Tokyo Women’s Medical University, Tokyo, Japan

Search this article

Description

A successful case of human atrial natriuretic peptide (HANP) infusion therapy for a neonate who developed congestive heart failure (CHF) after total repair of total anomalous pulmonary venous connection was performed on the first day of life. Following 14h of HANP infusion at incremental doses of 0.125-0.25μg·kg-1·min-1, urine output and hemodynamics dramatically improved. Urine output increased from 1.1 to 10.6ml/h (p<0.0001) and good urinary output (13.0ml/h) was maintained even after discontinuation of the infusion. During the infusion, the heart rate decreased from 166 to 152 beats/min (p<0.0001), and the systemic systolic blood pressure increased from 82 to 103 mmHg (p<0.0001). Central venous pressure was not significantly affected by HANP infusion. This is the first successful case of HANP infusion therapy as the first treatment of post-operative pulmonary hypertension in this age group. This therapy can be used safely and may be useful in neonates with CHF resulting from other causes, but more investigation is needed.

Journal

References(9)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top