Association between Perinatal Status and Insulin Resistance in Neonates during the Birth Period

DOI Web Site Web Site 被引用文献1件 参考文献20件
  • Nagano Nobuhiko
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Urakami Tatsuhiko
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Fuwa Kazumasa
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Kayama Kazunori
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Kato Ryota
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Taguchi Yousuke
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Yoshikawa Kayo
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Usukura Yukihiro
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Hosono Shigeharu
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Takahashi Shigeru
    Department of Pediatrics and Child Health, Nihon University School of Medicine
  • Takahashi Shori
    Department of Pediatrics and Child Health, Nihon University School of Medicine

この論文をさがす

抄録

The aim of this study was to assess the association between perinatal status and insulin resistance in neonates during the birth period. The subjects were 49 neonates (27 boys, 22 girls) who had been admitted to the neonatal intensive care unit at Nihon University Itabashi Hospital within 2 h after birth. We retrospectively analyzed the associations between perinatal status (Apgar score, sex, gestational age, birth weight, etc.) and insulin resistance (assessed by plasma immunoreactive insulin (IRI), plasma cortisol, homeostatic model analysis ratio (HOMA-R), quantitative insulin sensitivity check index (QUICKI), plasma glucose/IRI ratio, and plasma IRI/cortisol ratio) based on the medical records. The preterm neonates had significantly lower plasma cortisol levels (P = 0.02) and significantly higher plasma IRI/cortisol ratios (P = 0.04) compared with the full-term neonates. No significant differences were found in any of the parameters between neonates with asphyxia and those without. In cases with hyperinsulinemia, male predominance was significant (P < 0.01) in neonates with hypoglycemia; furthermore, birth weight, HOMA-R, and plasma glucose/IRI ratio tended to be lower (P = 0.07, P = 0.01 and P < 0.01, respectively), while QUICKI and plasma IRI/cortisol ratio tended to be higher (P = 0.02 and P = 0.09, respectively) in neonates with hypoglycemia compared with those without. One possible reason for these findings could be the immaturity of the hypothalamic-pituitary-adrenal axis in preterm infants. There was no significant correlation between perinatal status and the indices of insulin resistance in neonates during the birth period.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (20)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ